Lack of CFTR in Skeletal Muscle Predisposes to Muscle Wasting and Diaphragm Muscle Pump Failure in Cystic Fibrosis Mice

Cystic fibrosis (CF) patients often have reduced mass and strength of skeletal muscles, including the diaphragm, the primary muscle of respiration. Here we show that lack of the CF transmembrane conductance regulator (CFTR) plays an intrinsic role in skeletal muscle atrophy and dysfunction. In norma...

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Detalles Bibliográficos
Autores principales: Divangahi, Maziar, Balghi, Haouaria, Danialou, Gawiyou, Comtois, Alain S., Demoule, Alexandre, Ernest, Sheila, Haston, Christina, Robert, Renaud, Hanrahan, John W., Radzioch, Danuta, Petrof, Basil J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709446/
https://www.ncbi.nlm.nih.gov/pubmed/19649303
http://dx.doi.org/10.1371/journal.pgen.1000586

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