Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors

Alzheimer’s disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with different pharmacological profile could be an evolving, promising th...

Descripción completa

Detalles Bibliográficos
Autores principales: Prasad, S.B. Benaka, Kumar, Y.C. Sunil, Kumar, C.S. Ananda, Sadashiva, C.T, Vinaya, K, Rangappa, K.S
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709467/
https://www.ncbi.nlm.nih.gov/pubmed/19662135
http://dx.doi.org/10.2174/1874104500701010004
_version_ 1782169295921348608
author Prasad, S.B. Benaka
Kumar, Y.C. Sunil
Kumar, C.S. Ananda
Sadashiva, C.T
Vinaya, K
Rangappa, K.S
author_facet Prasad, S.B. Benaka
Kumar, Y.C. Sunil
Kumar, C.S. Ananda
Sadashiva, C.T
Vinaya, K
Rangappa, K.S
author_sort Prasad, S.B. Benaka
collection PubMed
description Alzheimer’s disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with different pharmacological profile could be an evolving, promising therapeutic approach for the treatment of AD. Thus, providing a symptomatic treatment for this disease are cholinomimetics with the pharmacological profile of Acetylcholinesterase (AChE) inhibitors. In view of this, we have synthesized novel 3-aryl-N-methyl-1,2,5,6-tetrahydropyridine derivatives 5a-k by Suzuki coupling and screened the efficacy of these derivatives for their AChE inhibitor activity.
format Text
id pubmed-2709467
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Bentham Science Publishers Ltd.
record_format MEDLINE/PubMed
spelling pubmed-27094672009-08-06 Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors Prasad, S.B. Benaka Kumar, Y.C. Sunil Kumar, C.S. Ananda Sadashiva, C.T Vinaya, K Rangappa, K.S Open Med Chem J Article Alzheimer’s disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with different pharmacological profile could be an evolving, promising therapeutic approach for the treatment of AD. Thus, providing a symptomatic treatment for this disease are cholinomimetics with the pharmacological profile of Acetylcholinesterase (AChE) inhibitors. In view of this, we have synthesized novel 3-aryl-N-methyl-1,2,5,6-tetrahydropyridine derivatives 5a-k by Suzuki coupling and screened the efficacy of these derivatives for their AChE inhibitor activity. Bentham Science Publishers Ltd. 2007-09-05 /pmc/articles/PMC2709467/ /pubmed/19662135 http://dx.doi.org/10.2174/1874104500701010004 Text en 2007 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Prasad, S.B. Benaka
Kumar, Y.C. Sunil
Kumar, C.S. Ananda
Sadashiva, C.T
Vinaya, K
Rangappa, K.S
Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
title Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
title_full Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
title_fullStr Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
title_full_unstemmed Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
title_short Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors
title_sort synthesis of novel 3-aryl-n-methyl-1,2,5,6-tetrahydropyridine derivatives by suzuki coupling: as acetyl cholinesterase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709467/
https://www.ncbi.nlm.nih.gov/pubmed/19662135
http://dx.doi.org/10.2174/1874104500701010004
work_keys_str_mv AT prasadsbbenaka synthesisofnovel3arylnmethyl1256tetrahydropyridinederivativesbysuzukicouplingasacetylcholinesteraseinhibitors
AT kumarycsunil synthesisofnovel3arylnmethyl1256tetrahydropyridinederivativesbysuzukicouplingasacetylcholinesteraseinhibitors
AT kumarcsananda synthesisofnovel3arylnmethyl1256tetrahydropyridinederivativesbysuzukicouplingasacetylcholinesteraseinhibitors
AT sadashivact synthesisofnovel3arylnmethyl1256tetrahydropyridinederivativesbysuzukicouplingasacetylcholinesteraseinhibitors
AT vinayak synthesisofnovel3arylnmethyl1256tetrahydropyridinederivativesbysuzukicouplingasacetylcholinesteraseinhibitors
AT rangappaks synthesisofnovel3arylnmethyl1256tetrahydropyridinederivativesbysuzukicouplingasacetylcholinesteraseinhibitors

Ejemplares similares