The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method

In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently i...

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Detalles Bibliográficos
Autores principales: Saracoglu, Murat, Kandemirli, Fatma
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709473/
https://www.ncbi.nlm.nih.gov/pubmed/19662147
http://dx.doi.org/10.2174/1874104500802010075
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author Saracoglu, Murat
Kandemirli, Fatma
author_facet Saracoglu, Murat
Kandemirli, Fatma
author_sort Saracoglu, Murat
collection PubMed
description In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series.
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spelling pubmed-27094732009-08-06 The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method Saracoglu, Murat Kandemirli, Fatma Open Med Chem J Article In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series. Bentham Open 2008-08-06 /pmc/articles/PMC2709473/ /pubmed/19662147 http://dx.doi.org/10.2174/1874104500802010075 Text en © Saracoglu and Kandemirli; Licensee Bentham Open http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Saracoglu, Murat
Kandemirli, Fatma
The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
title The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
title_full The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
title_fullStr The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
title_full_unstemmed The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
title_short The Investigation of Structure-Activity Relationships of Tacrine Analogues: Electronic-Topological Method
title_sort investigation of structure-activity relationships of tacrine analogues: electronic-topological method
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709473/
https://www.ncbi.nlm.nih.gov/pubmed/19662147
http://dx.doi.org/10.2174/1874104500802010075
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