Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction

Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL–HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Holzer, Marcel, Ziegler, Sigrid, Kronenberger, Bernd, Klein, Christian D, Hartmann, Rolf W
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709478/
https://www.ncbi.nlm.nih.gov/pubmed/19662141
http://dx.doi.org/10.2174/1874104500802010021
_version_ 1782169298514477056
author Holzer, Marcel
Ziegler, Sigrid
Kronenberger, Bernd
Klein, Christian D
Hartmann, Rolf W
author_facet Holzer, Marcel
Ziegler, Sigrid
Kronenberger, Bernd
Klein, Christian D
Hartmann, Rolf W
author_sort Holzer, Marcel
collection PubMed
description Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL–HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.
format Text
id pubmed-2709478
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-27094782009-08-06 Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction Holzer, Marcel Ziegler, Sigrid Kronenberger, Bernd Klein, Christian D Hartmann, Rolf W Open Med Chem J Article Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL–HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells. Bentham Open 2008-04-15 /pmc/articles/PMC2709478/ /pubmed/19662141 http://dx.doi.org/10.2174/1874104500802010021 Text en © Holzer et al.; Licensee Bentham Open http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Holzer, Marcel
Ziegler, Sigrid
Kronenberger, Bernd
Klein, Christian D
Hartmann, Rolf W
Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
title Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
title_full Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
title_fullStr Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
title_full_unstemmed Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
title_short Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction
title_sort microwave-assisted syntheses of amino acid ester substituted benzoic acid amides: potential inhibitors of human cd81-receptor hcv-e2 interaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709478/
https://www.ncbi.nlm.nih.gov/pubmed/19662141
http://dx.doi.org/10.2174/1874104500802010021
work_keys_str_mv AT holzermarcel microwaveassistedsynthesesofaminoacidestersubstitutedbenzoicacidamidespotentialinhibitorsofhumancd81receptorhcve2interaction
AT zieglersigrid microwaveassistedsynthesesofaminoacidestersubstitutedbenzoicacidamidespotentialinhibitorsofhumancd81receptorhcve2interaction
AT kronenbergerbernd microwaveassistedsynthesesofaminoacidestersubstitutedbenzoicacidamidespotentialinhibitorsofhumancd81receptorhcve2interaction
AT kleinchristiand microwaveassistedsynthesesofaminoacidestersubstitutedbenzoicacidamidespotentialinhibitorsofhumancd81receptorhcve2interaction
AT hartmannrolfw microwaveassistedsynthesesofaminoacidestersubstitutedbenzoicacidamidespotentialinhibitorsofhumancd81receptorhcve2interaction

Ejemplares similares