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p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication

RNA-interference (RNAi) is a potent tool for specific gene silencing. In this study, we developed an adenovirus for conditional replication in p53-dysfunctional tumor cells that uses p53-selective expression of a microRNA-network directed against essential adenoviral genes. Compared to a control vir...

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Detalles Bibliográficos
Autores principales:	Gürlevik, Engin, Woller, Norman, Schache, Peter, Malek, Nisar P., Wirth, Thomas C., Zender, Lars, Manns, Michael P., Kubicka, Stefan, Kühnel, Florian
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709585/ https://www.ncbi.nlm.nih.gov/pubmed/19443444 http://dx.doi.org/10.1093/nar/gkp374

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