Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In the co...

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Detalles Bibliográficos
Autores principales: Tokuhira, Michihide, Hanzawa, Kyoko, Watanabe, Reiko, Sekiguchi, Yasunobu, Nemoto, Tomoe, Toyozumi, Yasuo, Tamaru, Jun-ichi, Itoyama, Shinji, Suzuki, Katsuya, Kameda, Hideto, Mori, Shigehisa, Kizaki, Masahiro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709901/
https://www.ncbi.nlm.nih.gov/pubmed/19566938
http://dx.doi.org/10.1186/1756-8722-2-27
Descripción
Sumario:Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In the contrary, acute myeloid leukemia with multilineage dysplasia (AML-MLD) has never been documented to be present concomitantly with the above two conditions. In this report we present a case of an autopsy-proven co-existence of AML-MLD and EBV-associated T-LPD in a patient with RA.

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