Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection

Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 1...

Descripción completa

Detalles Bibliográficos
Autor principal: Horsley, Valerie
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711585/
https://www.ncbi.nlm.nih.gov/pubmed/19487452
http://dx.doi.org/10.1083/jcb.200904125
_version_ 1782169444628299776
author Horsley, Valerie
author_facet Horsley, Valerie
author_sort Horsley, Valerie
collection PubMed
description Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185:811–826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of β-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2.
format Text
id pubmed-2711585
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-27115852009-12-01 Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection Horsley, Valerie J Cell Biol Reviews Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185:811–826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of β-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2. The Rockefeller University Press 2009-06-01 /pmc/articles/PMC2711585/ /pubmed/19487452 http://dx.doi.org/10.1083/jcb.200904125 Text en © 2009 Horsley This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Horsley, Valerie
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
title Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
title_full Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
title_fullStr Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
title_full_unstemmed Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
title_short Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
title_sort epigenetics, wnt signaling, and stem cells: the pygo2 connection
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711585/
https://www.ncbi.nlm.nih.gov/pubmed/19487452
http://dx.doi.org/10.1083/jcb.200904125
work_keys_str_mv AT horsleyvalerie epigeneticswntsignalingandstemcellsthepygo2connection

Ejemplares similares