During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

Loss of myofibrillar proteins is a hallmark of atrophying muscle. Expression of muscle RING-finger 1 (MuRF1), a ubiquitin ligase, is markedly induced during atrophy, and MuRF1 deletion attenuates muscle wasting. We generated mice expressing a Ring-deletion mutant MuRF1, which binds but cannot ubiqui...

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Detalles Bibliográficos
Autores principales: Cohen, Shenhav, Brault, Jeffrey J., Gygi, Steven P., Glass, David J., Valenzuela, David M., Gartner, Carlos, Latres, Esther, Goldberg, Alfred L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711608/
https://www.ncbi.nlm.nih.gov/pubmed/19506036
http://dx.doi.org/10.1083/jcb.200901052

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