Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

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Genomic instability is a hallmark of human cancers. Spindle assembly checkpoint (SAC) is a critical cellular mechanism that prevents chromosome missegregation and therefore aneuploidy by blocking premature separation of sister chromatids. Thus, SAC, much like the DNA damage checkpoint, is essential...

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Detalles Bibliográficos
Autores principales: Li, Min, Fang, Xiao, Wei, Zhubo, York, J. Philippe, Zhang, Pumin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711613/
https://www.ncbi.nlm.nih.gov/pubmed/19528295
http://dx.doi.org/10.1083/jcb.200904020

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