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Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice
Genomic instability is a hallmark of human cancers. Spindle assembly checkpoint (SAC) is a critical cellular mechanism that prevents chromosome missegregation and therefore aneuploidy by blocking premature separation of sister chromatids. Thus, SAC, much like the DNA damage checkpoint, is essential...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711613/ https://www.ncbi.nlm.nih.gov/pubmed/19528295 http://dx.doi.org/10.1083/jcb.200904020 |
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