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The role of aneuploidy in promoting and suppressing tumors

Impaired mitotic checkpoint signaling can both promote and suppress tumors. The mitotic checkpoint targets Cdc20, the specificity factor of the ubiquitin ligase that promotes anaphase by targeting cyclin B and securin for destruction. In this issue, Li et al. (2009. J. Cell Biol. doi:10.1083/jcb.200...

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Detalles Bibliográficos
Autores principales:	Weaver, Beth A.A., Cleveland, Don W.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711620/ https://www.ncbi.nlm.nih.gov/pubmed/19528293 http://dx.doi.org/10.1083/jcb.200905098

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