Cargando…

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

BACKGROUND: In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an AT-II receptor antagonist. We now aimed to investigate the effect of treati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Failli, Paola, Alfarano, Chiara, Franchi-Micheli, Sergio, Mannucci, Edoardo, Cerbai, Elisabetta, Mugelli, Alessandro, Raimondi, Laura
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711933/ https://www.ncbi.nlm.nih.gov/pubmed/19545435 http://dx.doi.org/10.1186/1475-2840-8-32

Ejemplares similares

Angiotensin-II Drives Human Satellite Cells Toward Hypertrophy and Myofibroblast Trans-Differentiation by Two Independent Pathways
por: Laurino, Annunziatina, et al.
Publicado: (2019)

Exogenous Angiotensin I Metabolism in Aorta Isolated from Streptozotocin Treated Diabetic Rats
por: Wołkow, P. P., et al.
Publicado: (2016)

Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias
por: Johnson, Daniel M., et al.
Publicado: (2019)

Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan
por: Hyeon, Jin Seong, et al.
Publicado: (2020)

Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats
por: Ceron, Carla S., et al.
Publicado: (2017)

Altered Ca(2+) and Na(+) Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
por: Coppini, Raffaele, et al.
Publicado: (2018)

Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer
por: Hashemzehi, Milad, et al.
Publicado: (2021)

Black Ginseng Extract Counteracts Streptozotocin-Induced Diabetes in Mice
por: Kim, Jun Ho, et al.
Publicado: (2016)

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma
por: Coulson, Rhiannon, et al.
Publicado: (2017)

Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands
por: Cano, Isadora Prado, et al.
Publicado: (2019)

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries
por: AlSaad, Abdulaziz M.S., et al.
Publicado: (2020)

The effect of angiotensin 1-7 and losartan on renal ischemic/reperfusion injury in male rats
por: Safari, Tahereh, et al.
Publicado: (2019)

Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats
por: Moke, Emuesiri Goodies, et al.
Publicado: (2023)

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
por: Paci, Michelangelo, et al.
Publicado: (2012)

HCN Channels Modulators: The Need for Selectivity
por: Romanelli, Maria Novella, et al.
Publicado: (2016)

Effect of Angiotensin II Type 1 Receptor Antagonist, Losartan on Inflammatory Factor in Atherosclerotic Rabbits
por: Xu, Yan-min, et al.
Publicado: (2013)

Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment
por: Coppini, Raffaele, et al.
Publicado: (2013)

Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells
por: Cambados, Nadia, et al.
Publicado: (2017)

Angiotensin II type 2 receptor correlates with therapeutic effects of losartan in rats with adjuvant-induced arthritis
por: Wang, Di, et al.
Publicado: (2013)

Effects of Antihypertensive Agents on Intestinal Contractility in the Spontaneously Hypertensive Rat: Angiotensin Receptor System Downregulation by Losartan
por: Patten, Glen Stephen, et al.
Publicado: (2017)

Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model
por: Graus-Nunes, Francielle, et al.
Publicado: (2019)

Diminished antiproteinuric effect of the angiotensin receptor blocker losartan during high potassium intake in patients with CKD
por: Wouda, Rosa D, et al.
Publicado: (2021)

Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells
por: Panza, Salvatore, et al.
Publicado: (2021)

Losartan protects human stem cell-derived cardiomyocytes from angiotensin II-induced alcoholic cardiotoxicity
por: Song, Yuanxiu, et al.
Publicado: (2022)

Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes
por: Thimm, Chantelle, et al.
Publicado: (2023)

Losartan-induced Pancreatitis
por: Anwar, Shamsuddin M, et al.
Publicado: (2019)

Effects of sitagliptin on ß-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta
por: MÜDERRİSOĞLU, Ayhanım Elif, et al.
Publicado: (2021)

Proinflammatory Role of Angiotensin II in the Aorta of Normotensive Mice
por: de Lima, Rariane Silva, et al.
Publicado: (2019)

Histomorphometry Changes and Decreased Reactivity to Angiotensin II in the Ileum and Colon of Streptozotocin-Induced Diabetic Rats
por: Esteves-Monteiro, Marisa, et al.
Publicado: (2022)

Effects of Angiotensin Receptor Blockers on Streptozotocin-Induced Diabetic Cataracts
por: Ishigooka, Gaku, et al.
Publicado: (2023)

Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra
por: Grammatopoulos, Tom N, et al.
Publicado: (2007)

INHERIT (INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy—a Randomised Intervention Trial with losartan)
por: Olivotto, Iacopo, et al.
Publicado: (2015)

The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats
por: Siregar, Safendra, et al.
Publicado: (2023)

Impaired Relaxation in Aorta from Streptozotocin-diabetic Rats: Effect of Aminoguanidine (AMNG) Treatment
por: Özyazgan, Sibel, et al.
Publicado: (2000)

Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta
por: Abbasnezhad, Abbasali, et al.
Publicado: (2016)

Is the combination of enalapril and losartan irrational?
por: Parmar, D.M., et al.
Publicado: (2008)

Losartan, an angiotensin-II type 1 receptor blocker, attenuates the liver fibrosis development of non-alcoholic steatohepatitis in the rat
por: Yoshiji, Hitoshi, et al.
Publicado: (2009)

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ(10), and angiotensin receptor blocker, losartan, on cardiovascular function
por: McLachlan, Jennifer, et al.
Publicado: (2014)

Therapeutic Effect of Losartan, an Angiotensin II Type 1 Receptor Antagonist, on CCl(4)-Induced Skeletal Muscle Injury
por: Hwang, Ok-Kyung, et al.
Publicado: (2016)

The Angiotensin II Receptor Blocker Losartan Sensitizes Human Liver Cancer Cells to Lenvatinib-Mediated Cytostatic and Angiostatic Effects
por: Takagi, Hirotetsu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vl5fgn97u4v6d8gluf62lderri