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Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

BACKGROUND: In streptozotocin-injected rats (STZ-rats), we previously demonstrated a role for angiotensin II (AT-II) in cardiac remodelling and insulin resistance partially counteracted by in vivo treatment with losartan, an AT-II receptor antagonist. We now aimed to investigate the effect of treati...

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Detalles Bibliográficos
Autores principales:	Failli, Paola, Alfarano, Chiara, Franchi-Micheli, Sergio, Mannucci, Edoardo, Cerbai, Elisabetta, Mugelli, Alessandro, Raimondi, Laura
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711933/ https://www.ncbi.nlm.nih.gov/pubmed/19545435 http://dx.doi.org/10.1186/1475-2840-8-32

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