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Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004

BACKGROUND: Overuse of broad-spectrum antibiotics is associated with antibiotic resistance. Acute otitis media (AOM) is responsible for a large proportion of antibiotics prescribed for US children. Rates of broad-spectrum antibiotic prescribing for AOM are unknown. METHODS: Analysis of the National...

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Autores principales: Coco, Andrew S, Horst, Michael A, Gambler, Angela S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711950/
https://www.ncbi.nlm.nih.gov/pubmed/19552819
http://dx.doi.org/10.1186/1471-2431-9-41
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author Coco, Andrew S
Horst, Michael A
Gambler, Angela S
author_facet Coco, Andrew S
Horst, Michael A
Gambler, Angela S
author_sort Coco, Andrew S
collection PubMed
description BACKGROUND: Overuse of broad-spectrum antibiotics is associated with antibiotic resistance. Acute otitis media (AOM) is responsible for a large proportion of antibiotics prescribed for US children. Rates of broad-spectrum antibiotic prescribing for AOM are unknown. METHODS: Analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 1998 to 2004 (N = 6,878). Setting is office-based physicians, hospital outpatient departments, and emergency departments. Patients are children aged 12 years and younger prescribed antibiotics for acute otitis media. Main outcome measure is percentage of broad-spectrum antibiotics, defined as amoxicillin/clavulanate, macrolides, cephalosporins and quinolones. RESULTS: Broad-spectrum prescribing for acute otitis media increased from 34% of visits in 1998 to 45% of visits in 2004 (P < .001 for trend). The trend was primarily attributable to an increase in prescribing of amoxicillin/clavulanate (8% to 15%; P < .001 for trend) and macrolides (9% to 15%; P < .001 for trend). Prescribing remained stable for amoxicillin and cephalosporins while decreasing for narrow-spectrum agents (12% to 3%; P < .001 for trend) over the study period. Independent predictors of broad-spectrum antibiotic prescribing were ear pain, non-white race, public and other insurance (compared to private), hospital outpatient department setting, emergency department setting, and West region (compared to South and Midwest regions), each of which was associated with lower rates of broad-spectrum prescribing. Age and fever were not associated with prescribing choice. CONCLUSION: Prescribing of broad-spectrum antibiotics for acute otitis media has steadily increased from 1998 to 2004. Associations with non-clinical factors suggest potential for improvement in prescribing practice.
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spelling pubmed-27119502009-07-17 Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004 Coco, Andrew S Horst, Michael A Gambler, Angela S BMC Pediatr Research Article BACKGROUND: Overuse of broad-spectrum antibiotics is associated with antibiotic resistance. Acute otitis media (AOM) is responsible for a large proportion of antibiotics prescribed for US children. Rates of broad-spectrum antibiotic prescribing for AOM are unknown. METHODS: Analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 1998 to 2004 (N = 6,878). Setting is office-based physicians, hospital outpatient departments, and emergency departments. Patients are children aged 12 years and younger prescribed antibiotics for acute otitis media. Main outcome measure is percentage of broad-spectrum antibiotics, defined as amoxicillin/clavulanate, macrolides, cephalosporins and quinolones. RESULTS: Broad-spectrum prescribing for acute otitis media increased from 34% of visits in 1998 to 45% of visits in 2004 (P < .001 for trend). The trend was primarily attributable to an increase in prescribing of amoxicillin/clavulanate (8% to 15%; P < .001 for trend) and macrolides (9% to 15%; P < .001 for trend). Prescribing remained stable for amoxicillin and cephalosporins while decreasing for narrow-spectrum agents (12% to 3%; P < .001 for trend) over the study period. Independent predictors of broad-spectrum antibiotic prescribing were ear pain, non-white race, public and other insurance (compared to private), hospital outpatient department setting, emergency department setting, and West region (compared to South and Midwest regions), each of which was associated with lower rates of broad-spectrum prescribing. Age and fever were not associated with prescribing choice. CONCLUSION: Prescribing of broad-spectrum antibiotics for acute otitis media has steadily increased from 1998 to 2004. Associations with non-clinical factors suggest potential for improvement in prescribing practice. BioMed Central 2009-06-24 /pmc/articles/PMC2711950/ /pubmed/19552819 http://dx.doi.org/10.1186/1471-2431-9-41 Text en Copyright © 2009 Coco et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Coco, Andrew S
Horst, Michael A
Gambler, Angela S
Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004
title Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004
title_full Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004
title_fullStr Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004
title_full_unstemmed Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004
title_short Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004
title_sort trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the united states, 1998–2004
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711950/
https://www.ncbi.nlm.nih.gov/pubmed/19552819
http://dx.doi.org/10.1186/1471-2431-9-41
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