T-bet controls regulatory T cell homeostasis and function during type-1 inflammation

Several subsets of Foxp3(+) regulatory T (T(reg)) cells work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure. We show that in response to interferon-γ, Foxp3(+) T(reg) cells upregulated the T he...

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Autores principales: Koch, Meghan A., Tucker-Heard, Glady’s, Perdue, Nikole R., Killebrew, Justin R., Urdahl, Kevin B., Campbell, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712126/
https://www.ncbi.nlm.nih.gov/pubmed/19412181
http://dx.doi.org/10.1038/ni.1731
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author Koch, Meghan A.
Tucker-Heard, Glady’s
Perdue, Nikole R.
Killebrew, Justin R.
Urdahl, Kevin B.
Campbell, Daniel J.
author_facet Koch, Meghan A.
Tucker-Heard, Glady’s
Perdue, Nikole R.
Killebrew, Justin R.
Urdahl, Kevin B.
Campbell, Daniel J.
author_sort Koch, Meghan A.
collection PubMed
description Several subsets of Foxp3(+) regulatory T (T(reg)) cells work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure. We show that in response to interferon-γ, Foxp3(+) T(reg) cells upregulated the T helper 1 (T(H)1)-specifying transcription factor T-bet. T-bet promoted expression of the chemokine receptor CXCR3 on T(reg) cells, and T-bet(+) T(reg) cells accumulated at sites of T(H)1-mediated inflammation. Furthermore, T-bet expression was required for the homeostasis and function of T(reg) cells during type-1 inflammation. Thus, within a subset of CD4(+) T cells, the activities of Foxp3 and T-bet are overlaid, resulting in T(reg) cells with unique homeostatic and migratory properties optimized for suppression of T(H)1 responses in vivo.
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spelling pubmed-27121262009-12-01 T-bet controls regulatory T cell homeostasis and function during type-1 inflammation Koch, Meghan A. Tucker-Heard, Glady’s Perdue, Nikole R. Killebrew, Justin R. Urdahl, Kevin B. Campbell, Daniel J. Nat Immunol Article Several subsets of Foxp3(+) regulatory T (T(reg)) cells work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure. We show that in response to interferon-γ, Foxp3(+) T(reg) cells upregulated the T helper 1 (T(H)1)-specifying transcription factor T-bet. T-bet promoted expression of the chemokine receptor CXCR3 on T(reg) cells, and T-bet(+) T(reg) cells accumulated at sites of T(H)1-mediated inflammation. Furthermore, T-bet expression was required for the homeostasis and function of T(reg) cells during type-1 inflammation. Thus, within a subset of CD4(+) T cells, the activities of Foxp3 and T-bet are overlaid, resulting in T(reg) cells with unique homeostatic and migratory properties optimized for suppression of T(H)1 responses in vivo. 2009-05-03 2009-06 /pmc/articles/PMC2712126/ /pubmed/19412181 http://dx.doi.org/10.1038/ni.1731 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Koch, Meghan A.
Tucker-Heard, Glady’s
Perdue, Nikole R.
Killebrew, Justin R.
Urdahl, Kevin B.
Campbell, Daniel J.
T-bet controls regulatory T cell homeostasis and function during type-1 inflammation
title T-bet controls regulatory T cell homeostasis and function during type-1 inflammation
title_full T-bet controls regulatory T cell homeostasis and function during type-1 inflammation
title_fullStr T-bet controls regulatory T cell homeostasis and function during type-1 inflammation
title_full_unstemmed T-bet controls regulatory T cell homeostasis and function during type-1 inflammation
title_short T-bet controls regulatory T cell homeostasis and function during type-1 inflammation
title_sort t-bet controls regulatory t cell homeostasis and function during type-1 inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712126/
https://www.ncbi.nlm.nih.gov/pubmed/19412181
http://dx.doi.org/10.1038/ni.1731
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