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Current concepts in the pathophysiology of glaucoma

Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Exte...

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Autores principales: Agarwal, Renu, Gupta, Suresh K, Agarwal, Puneet, Saxena, Rohit, Agrawal, Shyam S
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712693/
https://www.ncbi.nlm.nih.gov/pubmed/19574692
http://dx.doi.org/10.4103/0301-4738.53049
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author Agarwal, Renu
Gupta, Suresh K
Agarwal, Puneet
Saxena, Rohit
Agrawal, Shyam S
author_facet Agarwal, Renu
Gupta, Suresh K
Agarwal, Puneet
Saxena, Rohit
Agrawal, Shyam S
author_sort Agarwal, Renu
collection PubMed
description Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Extensive investigations into the pathophysiology of glaucoma now reveal the role of multiple factors in the development of retinal ganglion cell death. A better understanding of the pathophysiological mechanisms involved in the onset and progression of glaucomatous optic neuropathy is crucial in the development of better therapeutic options. This review is an effort to summarize the current concepts in the pathophysiology of glaucoma so that newer therapeutic targets can be recognized. The literature available in the National Medical Library and online Pubmed search engine was used for literature review.
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spelling pubmed-27126932009-07-29 Current concepts in the pathophysiology of glaucoma Agarwal, Renu Gupta, Suresh K Agarwal, Puneet Saxena, Rohit Agrawal, Shyam S Indian J Ophthalmol Review Article Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Extensive investigations into the pathophysiology of glaucoma now reveal the role of multiple factors in the development of retinal ganglion cell death. A better understanding of the pathophysiological mechanisms involved in the onset and progression of glaucomatous optic neuropathy is crucial in the development of better therapeutic options. This review is an effort to summarize the current concepts in the pathophysiology of glaucoma so that newer therapeutic targets can be recognized. The literature available in the National Medical Library and online Pubmed search engine was used for literature review. Medknow Publications 2009 /pmc/articles/PMC2712693/ /pubmed/19574692 http://dx.doi.org/10.4103/0301-4738.53049 Text en © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Agarwal, Renu
Gupta, Suresh K
Agarwal, Puneet
Saxena, Rohit
Agrawal, Shyam S
Current concepts in the pathophysiology of glaucoma
title Current concepts in the pathophysiology of glaucoma
title_full Current concepts in the pathophysiology of glaucoma
title_fullStr Current concepts in the pathophysiology of glaucoma
title_full_unstemmed Current concepts in the pathophysiology of glaucoma
title_short Current concepts in the pathophysiology of glaucoma
title_sort current concepts in the pathophysiology of glaucoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712693/
https://www.ncbi.nlm.nih.gov/pubmed/19574692
http://dx.doi.org/10.4103/0301-4738.53049
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