Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

OBJECTIVE: Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is a mediator of collagen deposition and promotes fibrosis. Adipose tissue collagen has recently been found to be linked with metabolic dysregulation. Therefore, we tested th...

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Detalles Bibliográficos
Autores principales: Kos, Katrina, Wong, Steve, Tan, Bee, Gummesson, Anders, Jernas, Margareta, Franck, Niclas, Kerrigan, David, Nystrom, Fredrik H., Carlsson, Lena M.S., Randeva, Harpal S., Pinkney, Jonathan H., Wilding, John P.H.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712789/
https://www.ncbi.nlm.nih.gov/pubmed/19509023
http://dx.doi.org/10.2337/db09-0211

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