Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway

Fibroblast growth factor 2 (FGF2) is a major regulator of developmental, pathological, and therapeutic angiogenesis. Its activity is partially mediated by binding to syndecan 4 (S4), a proteoglycan receptor. Angiogenesis requires polarized activation of the small guanosine triphosphatase Rac1, which...

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Detalles Bibliográficos
Autores principales: Elfenbein, Arye, Rhodes, John M., Meller, Julia, Schwartz, Martin A., Matsuda, Michiyuki, Simons, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712988/
https://www.ncbi.nlm.nih.gov/pubmed/19581409
http://dx.doi.org/10.1083/jcb.200810179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712988/
https://www.ncbi.nlm.nih.gov/pubmed/19581409
http://dx.doi.org/10.1083/jcb.200810179

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