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Protein kinase A–dependent modulation of Ca(2+) sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin
Protein kinase A (PKA)-dependent phosphorylation of troponin (Tn)I represents a major physiological mechanism during β-adrenergic stimulation in myocardium for the reduction of myofibrillar Ca(2+) sensitivity via weakening of the interaction with TnC. By taking advantage of thin filament reconstitut...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713144/ https://www.ncbi.nlm.nih.gov/pubmed/19433622 http://dx.doi.org/10.1085/jgp.200910206 |