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New angiotensins

Accumulation of a large body of evidence during the past two decades testifies to the complexity of the renin–angiotensin system (RAS). The incorporation of novel enzymatic pathways, resulting peptides, and their corresponding receptors into the biochemical cascade of the RAS provides a better under...

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Autores principales: Varagic, Jasmina, Trask, Aaron J., Jessup, Jewell A., Chappell, Mark C., Ferrario, Carlos M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713173/
https://www.ncbi.nlm.nih.gov/pubmed/18437333
http://dx.doi.org/10.1007/s00109-008-0340-4
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author Varagic, Jasmina
Trask, Aaron J.
Jessup, Jewell A.
Chappell, Mark C.
Ferrario, Carlos M.
author_facet Varagic, Jasmina
Trask, Aaron J.
Jessup, Jewell A.
Chappell, Mark C.
Ferrario, Carlos M.
author_sort Varagic, Jasmina
collection PubMed
description Accumulation of a large body of evidence during the past two decades testifies to the complexity of the renin–angiotensin system (RAS). The incorporation of novel enzymatic pathways, resulting peptides, and their corresponding receptors into the biochemical cascade of the RAS provides a better understanding of its role in the regulation of cardiovascular and renal function. Hence, in recent years, it became apparent that the balance between the two opposing effector peptides, angiotensin II and angiotensin-(1-7), may have a pivotal role in determining different cardiovascular pathophysiologies. Furthermore, our recent studies provide evidence for the functional relevance of a newly discovered rat peptide, containing two additional amino acid residues compared to angiotensin I, first defined as proangiotensin-12 [angiotensin-(1-12)]. This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor.
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spelling pubmed-27131732009-07-20 New angiotensins Varagic, Jasmina Trask, Aaron J. Jessup, Jewell A. Chappell, Mark C. Ferrario, Carlos M. J Mol Med (Berl) Review Accumulation of a large body of evidence during the past two decades testifies to the complexity of the renin–angiotensin system (RAS). The incorporation of novel enzymatic pathways, resulting peptides, and their corresponding receptors into the biochemical cascade of the RAS provides a better understanding of its role in the regulation of cardiovascular and renal function. Hence, in recent years, it became apparent that the balance between the two opposing effector peptides, angiotensin II and angiotensin-(1-7), may have a pivotal role in determining different cardiovascular pathophysiologies. Furthermore, our recent studies provide evidence for the functional relevance of a newly discovered rat peptide, containing two additional amino acid residues compared to angiotensin I, first defined as proangiotensin-12 [angiotensin-(1-12)]. This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor. Springer-Verlag 2008-04-25 2008 /pmc/articles/PMC2713173/ /pubmed/18437333 http://dx.doi.org/10.1007/s00109-008-0340-4 Text en © Springer-Verlag 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Varagic, Jasmina
Trask, Aaron J.
Jessup, Jewell A.
Chappell, Mark C.
Ferrario, Carlos M.
New angiotensins
title New angiotensins
title_full New angiotensins
title_fullStr New angiotensins
title_full_unstemmed New angiotensins
title_short New angiotensins
title_sort new angiotensins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713173/
https://www.ncbi.nlm.nih.gov/pubmed/18437333
http://dx.doi.org/10.1007/s00109-008-0340-4
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