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Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience
BACKGROUND: Micropapillary bladder cancer is a rare and aggressive variant of urothelial carcinoma. A retrospective review of our experience in management of patients with muscle-invasive or metastatic micropapillary bladder cancer was performed to better define the behavior of this disease. METHODS...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713271/ https://www.ncbi.nlm.nih.gov/pubmed/19534791 http://dx.doi.org/10.1186/1471-2490-9-5 |
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author | Heudel, Pierre El Karak, Fadi Ismaili, Nabil Droz, Jean-Pierre Flechon, Aude |
author_facet | Heudel, Pierre El Karak, Fadi Ismaili, Nabil Droz, Jean-Pierre Flechon, Aude |
author_sort | Heudel, Pierre |
collection | PubMed |
description | BACKGROUND: Micropapillary bladder cancer is a rare and aggressive variant of urothelial carcinoma. A retrospective review of our experience in management of patients with muscle-invasive or metastatic micropapillary bladder cancer was performed to better define the behavior of this disease. METHODS: We reviewed the records of the 11 patients with micropapillary bladder cancer who were evaluated and treated at Léon Bérard Cancer Center between 1994 and 2007, accounting for 1,2% of all urothelial tumors treated in this institution. RESULTS: Mean patients age was 60 years. The majority of patients (72%) were diagnosed after 2004. After a median follow-up of 31.7 months, median overall survival was 19 months. Two patients presented with stage II, one with stage III and eight with stage IV disease All 5 patients who had node positive metastases and treated with radical surgery and adjuvant chemotherapy relapsed and had a disease free survival of 9.6 months. CONCLUSION: Micropapillary bladder cancer is probably an underreported variant of urothelial carcinoma associated with poor prognosis. Adjuvant chemotherapy might have a questionable efficacy and the optimal treatment strategy is yet to be defined. |
format | Text |
id | pubmed-2713271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27132712009-07-21 Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience Heudel, Pierre El Karak, Fadi Ismaili, Nabil Droz, Jean-Pierre Flechon, Aude BMC Urol Research Article BACKGROUND: Micropapillary bladder cancer is a rare and aggressive variant of urothelial carcinoma. A retrospective review of our experience in management of patients with muscle-invasive or metastatic micropapillary bladder cancer was performed to better define the behavior of this disease. METHODS: We reviewed the records of the 11 patients with micropapillary bladder cancer who were evaluated and treated at Léon Bérard Cancer Center between 1994 and 2007, accounting for 1,2% of all urothelial tumors treated in this institution. RESULTS: Mean patients age was 60 years. The majority of patients (72%) were diagnosed after 2004. After a median follow-up of 31.7 months, median overall survival was 19 months. Two patients presented with stage II, one with stage III and eight with stage IV disease All 5 patients who had node positive metastases and treated with radical surgery and adjuvant chemotherapy relapsed and had a disease free survival of 9.6 months. CONCLUSION: Micropapillary bladder cancer is probably an underreported variant of urothelial carcinoma associated with poor prognosis. Adjuvant chemotherapy might have a questionable efficacy and the optimal treatment strategy is yet to be defined. BioMed Central 2009-06-17 /pmc/articles/PMC2713271/ /pubmed/19534791 http://dx.doi.org/10.1186/1471-2490-9-5 Text en Copyright © 2009 Heudel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Heudel, Pierre El Karak, Fadi Ismaili, Nabil Droz, Jean-Pierre Flechon, Aude Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience |
title | Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience |
title_full | Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience |
title_fullStr | Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience |
title_full_unstemmed | Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience |
title_short | Micropapillary bladder cancer: a review of Léon Bérard Cancer Center experience |
title_sort | micropapillary bladder cancer: a review of léon bérard cancer center experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713271/ https://www.ncbi.nlm.nih.gov/pubmed/19534791 http://dx.doi.org/10.1186/1471-2490-9-5 |
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