Trans-Dominant Inhibition of Prion Propagation In Vitro Is Not Mediated by an Accessory Cofactor

Previous studies identified prion protein (PrP) mutants which act as dominant negative inhibitors of prion formation through a mechanism hypothesized to require an unidentified species-specific cofactor termed protein X. To study the mechanism of dominant negative inhibition in vitro, we used recomb...

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Detalles Bibliográficos
Autores principales: Geoghegan, James C., Miller, Michael B., Kwak, Aimee H., Harris, Brent T., Supattapone, Surachai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713408/
https://www.ncbi.nlm.nih.gov/pubmed/19649330
http://dx.doi.org/10.1371/journal.ppat.1000535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713408/
https://www.ncbi.nlm.nih.gov/pubmed/19649330
http://dx.doi.org/10.1371/journal.ppat.1000535

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