Several Distinct Polycomb Complexes Regulate and Co-Localize on the INK4a Tumor Suppressor Locus

Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene. Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repre...

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Detalles Bibliográficos
Autores principales: Maertens, Goedele N., El Messaoudi-Aubert, Selma, Racek, Tomas, Stock, Julie K., Nicholls, James, Rodriguez-Niedenführ, Marc, Gil, Jesus, Peters, Gordon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713427/
https://www.ncbi.nlm.nih.gov/pubmed/19636380
http://dx.doi.org/10.1371/journal.pone.0006380

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