Cargando…

Pitfalls in TCR gene clonality testing: teaching cases

Clonality testing in T-lymphoproliferations has technically become relatively easy to perform in routine laboratories using standardized multiplex polymerase chain reaction protocols for T-cell receptor (TCR) gene analysis as developed by the BIOMED-2 Concerted Action BMH4-CT98-3936. Expertise with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Groenen, Patricia J. T. A., Langerak, Anton W., van Dongen, Jacques J. M., van Krieken, Johan H. J. M.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2008
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713482/ https://www.ncbi.nlm.nih.gov/pubmed/19669208 http://dx.doi.org/10.1007/s12308-008-0013-9

Ejemplares similares

EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
por: Langerak, A W, et al.
Publicado: (2012)

Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia
por: Kallemeijn, Martine J., et al.
Publicado: (2017)

PCR clonality detection in Hodgkin lymphoma
por: Hebeda, K. M., et al.
Publicado: (2009)

Memento for interprofessional learning
por: Groenen, Patricia J. T. A., et al.
Publicado: (2020)

Clonality assessment and detection of clonal diversity in classic Hodgkin lymphoma by next-generation sequencing of immunoglobulin gene rearrangements
por: van Bladel, Diede A. G., et al.
Publicado: (2021)

Correction to: Clonality assessment and detection of clonal diversity in classic Hodgkin lymphoma by next-generation sequencing of immunoglobulin gene rearrangements
por: van Bladel, Diede A. G., et al.
Publicado: (2021)

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging
por: Kallemeijn, Martine J., et al.
Publicado: (2018)

Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS
por: Scheijen, Blanca, et al.
Publicado: (2019)

Quantification of HTLV-1 Clonality and TCR Diversity
por: Laydon, Daniel J., et al.
Publicado: (2014)

Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study
por: van der Velden, Vincent H. J., et al.
Publicado: (2021)

A New and Simple TRG Multiplex PCR Assay for Assessment of T-cell Clonality: A Comparative Study from the EuroClonality Consortium
por: Armand, Marine, et al.
Publicado: (2019)

Clonotype definitions for immunogenetic studies: proposals from the EuroClonality NGS Working Group
por: Sofou, Electra, et al.
Publicado: (2023)

PID Comes Full Circle: Applications of V(D)J Recombination Excision Circles in Research, Diagnostics and Newborn Screening of Primary Immunodeficiency Disorders
por: van Zelm, Menno C., et al.
Publicado: (2011)

Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System
por: Yokosuka, Tadashi, et al.
Publicado: (2002)

Diagnostic significance of TCR gene clonal rearrangement analysis in early mycosis fungoides
por: Xu, Chen, et al.
Publicado: (2011)

Anti-TRBC1 Antibody-Based Flow Cytometric Detection of T-Cell Clonality: Standardization of Sample Preparation and Diagnostic Implementation
por: Muñoz-García, Noemí, et al.
Publicado: (2021)

Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL
por: Sandberg, Y, et al.
Publicado: (2014)

TCR-dependent differentiation of thymic Foxp3(+) cells is limited to small clonal sizes
por: Leung, Monica W.L., et al.
Publicado: (2009)

Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality
por: Bárcena, Paloma, et al.
Publicado: (2015)

T-lymphoblastic lymphoma/leukemia without clonal TCR gene rearrangements: case report and literature review
por: Wang, Jiuju, et al.
Publicado: (2021)

Clonal Relationship and Mutation Analysis in Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Associated With Diffuse Large B-cell Lymphoma
por: Berendsen, Madeleine R., et al.
Publicado: (2023)

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A
por: Howson, Lauren J., et al.
Publicado: (2018)

Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality
por: Shi, Tiffany, et al.
Publicado: (2023)

Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology
por: Groenen, Patricia J. T. A., et al.
Publicado: (2023)

Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study
por: Brüggemann, Monika, et al.
Publicado: (2019)

Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?
por: Aran, Andrea, et al.
Publicado: (2022)

Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS
por: Knecht, Henrik, et al.
Publicado: (2019)

Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection
por: Nunes-Alves, Cláudio, et al.
Publicado: (2015)

Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma
por: Frazzette, Nicholas, et al.
Publicado: (2020)

Durable benefit and change in TCR clonality with nivolumab in a Lynch syndrome–associated glioma
por: Cabezas-Camarero, Santiago, et al.
Publicado: (2022)

Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-κB pathway
por: Meijers, Ruud W.J., et al.
Publicado: (2020)

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer
por: Jahn, Lorenz, et al.
Publicado: (2016)

Validation and interpretation of IGH and TCR clonality testing by Ion Torrent S5 NGS for diagnosis and disease monitoring in B and T cell cancers
por: Lay, Lindsay, et al.
Publicado: (2020)

End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8(+) T Cell Subsets
por: Huang, Ling, et al.
Publicado: (2017)

PAX5 P80R-mutated B-cell acute lymphoblastic leukemia with transformation to histiocytic sarcoma: clonal evolution assessment using NGS-based immunoglobulin clonality and mutation analysis
por: Kroeze, Leonie I., et al.
Publicado: (2022)

Protein Profiling of B-Cell Lymphomas Using Tissue Biopsies: A Potential Tool for Small Samples in Pathology
por: Jansen, Corine, et al.
Publicado: (2008)

Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma
por: Schreuder, Max I., et al.
Publicado: (2017)

Clonal Elimination of the Pathogenic Allele as Diagnostic Pitfall in SAMD9L-Associated Neuropathy
por: Eggermann, K., et al.
Publicado: (2022)

TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer
por: Lecuelle, Julie, et al.
Publicado: (2021)

Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells
por: Kierkels, Guido J.J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0nb4ba1h56ei3n58905254rp67