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APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

Complexes involved in the γ/ϵ-secretase-regulated intramembranous proteolysis of substrates such as the amyloid-β precursor protein are composed primarily of presenilin (PS1 or PS2), nicastrin, anterior pharynx defective-1 (APH1), and PEN2. The presenilin aspartyl residues form the catalytic site, a...

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Detalles Bibliográficos
Autores principales:	Pardossi-Piquard, Raphaëlle, Yang, Seung-Pil, Kanemoto, Soshi, Gu, Yongjun, Chen, Fusheng, Böhm, Christopher, Sevalle, Jean, Li, Tong, Wong, Philip C., Checler, Frédéric, Schmitt-Ulms, Gerold, St. George-Hyslop, Peter, Fraser, Paul E.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713549/ https://www.ncbi.nlm.nih.gov/pubmed/19369254 http://dx.doi.org/10.1074/jbc.M109.000067

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