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Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
OBJECTIVE: To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglyce...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713640/ https://www.ncbi.nlm.nih.gov/pubmed/19487641 http://dx.doi.org/10.2337/dc09-0256 |
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author | Gatti, Alessandra Maranghi, Marianna Bacci, Simonetta Carallo, Claudio Gnasso, Agostino Mandosi, Elisabetta Fallarino, Mara Morano, Susanna Trischitta, Vincenzo Filetti, Sebastiano |
author_facet | Gatti, Alessandra Maranghi, Marianna Bacci, Simonetta Carallo, Claudio Gnasso, Agostino Mandosi, Elisabetta Fallarino, Mara Morano, Susanna Trischitta, Vincenzo Filetti, Sebastiano |
author_sort | Gatti, Alessandra |
collection | PubMed |
description | OBJECTIVE: To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS: A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1–1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1–1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05–1.18], P = 0.00017). CONCLUSIONS: Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes. |
format | Text |
id | pubmed-2713640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-27136402010-08-01 Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes Gatti, Alessandra Maranghi, Marianna Bacci, Simonetta Carallo, Claudio Gnasso, Agostino Mandosi, Elisabetta Fallarino, Mara Morano, Susanna Trischitta, Vincenzo Filetti, Sebastiano Diabetes Care Original Research OBJECTIVE: To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS: A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1–1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1–1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05–1.18], P = 0.00017). CONCLUSIONS: Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes. American Diabetes Association 2009-08 2009-06-01 /pmc/articles/PMC2713640/ /pubmed/19487641 http://dx.doi.org/10.2337/dc09-0256 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research Gatti, Alessandra Maranghi, Marianna Bacci, Simonetta Carallo, Claudio Gnasso, Agostino Mandosi, Elisabetta Fallarino, Mara Morano, Susanna Trischitta, Vincenzo Filetti, Sebastiano Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes |
title | Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes |
title_full | Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes |
title_fullStr | Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes |
title_full_unstemmed | Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes |
title_short | Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes |
title_sort | poor glycemic control is an independent risk factor for low hdl cholesterol in patients with type 2 diabetes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713640/ https://www.ncbi.nlm.nih.gov/pubmed/19487641 http://dx.doi.org/10.2337/dc09-0256 |
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