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Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes

OBJECTIVE: To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglyce...

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Autores principales: Gatti, Alessandra, Maranghi, Marianna, Bacci, Simonetta, Carallo, Claudio, Gnasso, Agostino, Mandosi, Elisabetta, Fallarino, Mara, Morano, Susanna, Trischitta, Vincenzo, Filetti, Sebastiano
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713640/
https://www.ncbi.nlm.nih.gov/pubmed/19487641
http://dx.doi.org/10.2337/dc09-0256
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author Gatti, Alessandra
Maranghi, Marianna
Bacci, Simonetta
Carallo, Claudio
Gnasso, Agostino
Mandosi, Elisabetta
Fallarino, Mara
Morano, Susanna
Trischitta, Vincenzo
Filetti, Sebastiano
author_facet Gatti, Alessandra
Maranghi, Marianna
Bacci, Simonetta
Carallo, Claudio
Gnasso, Agostino
Mandosi, Elisabetta
Fallarino, Mara
Morano, Susanna
Trischitta, Vincenzo
Filetti, Sebastiano
author_sort Gatti, Alessandra
collection PubMed
description OBJECTIVE: To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS: A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1–1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1–1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05–1.18], P = 0.00017). CONCLUSIONS: Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes.
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spelling pubmed-27136402010-08-01 Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes Gatti, Alessandra Maranghi, Marianna Bacci, Simonetta Carallo, Claudio Gnasso, Agostino Mandosi, Elisabetta Fallarino, Mara Morano, Susanna Trischitta, Vincenzo Filetti, Sebastiano Diabetes Care Original Research OBJECTIVE: To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS: We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS: A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1–1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1–1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05–1.18], P = 0.00017). CONCLUSIONS: Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes. American Diabetes Association 2009-08 2009-06-01 /pmc/articles/PMC2713640/ /pubmed/19487641 http://dx.doi.org/10.2337/dc09-0256 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Gatti, Alessandra
Maranghi, Marianna
Bacci, Simonetta
Carallo, Claudio
Gnasso, Agostino
Mandosi, Elisabetta
Fallarino, Mara
Morano, Susanna
Trischitta, Vincenzo
Filetti, Sebastiano
Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
title Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
title_full Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
title_fullStr Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
title_full_unstemmed Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
title_short Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes
title_sort poor glycemic control is an independent risk factor for low hdl cholesterol in patients with type 2 diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713640/
https://www.ncbi.nlm.nih.gov/pubmed/19487641
http://dx.doi.org/10.2337/dc09-0256
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