The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

BACKGROUND: The phosphatidylinositol 3′-kinase (PI3K)–AKT pathway is activated in many human cancers and plays a key role in cell proliferation and survival. A mutation (E17K) in the pleckstrin homology domain of the AKT1 results in constitutive AKT1 activation by means of localisation to the plasma...

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Detalles Bibliográficos
Autores principales: Shoji, K, Oda, K, Nakagawa, S, Hosokawa, S, Nagae, G, Uehara, Y, Sone, K, Miyamoto, Y, Hiraike, H, Hiraike-Wada, O, Nei, T, Kawana, K, Kuramoto, H, Aburatani, H, Yano, T, Taketani, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713716/
https://www.ncbi.nlm.nih.gov/pubmed/19491896
http://dx.doi.org/10.1038/sj.bjc.6605109

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