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C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk
Growing evidence points to a role for inflammation in prostate carcinogenesis. The significance of C-reactive protein (CRP), an inflammatory and innate immunity molecule, has not been evaluated thoroughly in prostate cancer (PC). In this study of 739 Finnish patients with PC and 760 healthy men, we...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714238/ https://www.ncbi.nlm.nih.gov/pubmed/19436291 http://dx.doi.org/10.1038/sj.bjc.6605081 |
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author | Eklund, C M Tammela, T L J Schleutker, J Hurme, M |
author_facet | Eklund, C M Tammela, T L J Schleutker, J Hurme, M |
author_sort | Eklund, C M |
collection | PubMed |
description | Growing evidence points to a role for inflammation in prostate carcinogenesis. The significance of C-reactive protein (CRP), an inflammatory and innate immunity molecule, has not been evaluated thoroughly in prostate cancer (PC). In this study of 739 Finnish patients with PC and 760 healthy men, we evaluated the associations of CRP genotypes and haplotypes with total PC risk and PC progression, using prostate-specific antigen (PSA) as a marker of metastatic disease. Although the haplotype frequencies were similar in patients and controls, an association between haplotype ACCCA and patients' PSA levels was found. The carriers more often had a high PSA than non-carriers (P=0.0002) and the SNP rs2794521 A-allele and rs1800947 C-allele carriers had a higher PSA than non-carriers (P=0.009 and P=0.0004, respectively). A trend for a younger age at diagnosis was found among the carriers of ACCCA (P=0.07) and the rs1800947 C-allele (P=0.06), as well as a trend for the latter to have more likely metastases (P=0.06), but not after Bonferroni correction (α=0.00208). This is the first study to suggest association between PSA and CRP variants in PC and, therefore, further studies are warranted. CRP alleles previously found to protect against increased CRP levels are now suggested to be associated with metastatic PC, indicated by elevated PSA. |
format | Text |
id | pubmed-2714238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-27142382010-06-16 C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk Eklund, C M Tammela, T L J Schleutker, J Hurme, M Br J Cancer Clinical Study Growing evidence points to a role for inflammation in prostate carcinogenesis. The significance of C-reactive protein (CRP), an inflammatory and innate immunity molecule, has not been evaluated thoroughly in prostate cancer (PC). In this study of 739 Finnish patients with PC and 760 healthy men, we evaluated the associations of CRP genotypes and haplotypes with total PC risk and PC progression, using prostate-specific antigen (PSA) as a marker of metastatic disease. Although the haplotype frequencies were similar in patients and controls, an association between haplotype ACCCA and patients' PSA levels was found. The carriers more often had a high PSA than non-carriers (P=0.0002) and the SNP rs2794521 A-allele and rs1800947 C-allele carriers had a higher PSA than non-carriers (P=0.009 and P=0.0004, respectively). A trend for a younger age at diagnosis was found among the carriers of ACCCA (P=0.07) and the rs1800947 C-allele (P=0.06), as well as a trend for the latter to have more likely metastases (P=0.06), but not after Bonferroni correction (α=0.00208). This is the first study to suggest association between PSA and CRP variants in PC and, therefore, further studies are warranted. CRP alleles previously found to protect against increased CRP levels are now suggested to be associated with metastatic PC, indicated by elevated PSA. Nature Publishing Group 2009-06-16 2009-05-12 /pmc/articles/PMC2714238/ /pubmed/19436291 http://dx.doi.org/10.1038/sj.bjc.6605081 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Study Eklund, C M Tammela, T L J Schleutker, J Hurme, M C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk |
title | C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk |
title_full | C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk |
title_fullStr | C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk |
title_full_unstemmed | C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk |
title_short | C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk |
title_sort | c-reactive protein haplotype is associated with high psa as a marker of metastatic prostate cancer but not with overall cancer risk |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714238/ https://www.ncbi.nlm.nih.gov/pubmed/19436291 http://dx.doi.org/10.1038/sj.bjc.6605081 |
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