Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect

Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to...

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Autores principales: Yang, G, Wu, L, Chen, S, Zhu, L, Huang, P, Tong, L, Zhao, Y, Zhao, G, Wang, J, Mei, T, Xu, A, Wang, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714242/
https://www.ncbi.nlm.nih.gov/pubmed/19455142
http://dx.doi.org/10.1038/sj.bjc.6605087
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author Yang, G
Wu, L
Chen, S
Zhu, L
Huang, P
Tong, L
Zhao, Y
Zhao, G
Wang, J
Mei, T
Xu, A
Wang, Y
author_facet Yang, G
Wu, L
Chen, S
Zhu, L
Huang, P
Tong, L
Zhao, Y
Zhao, G
Wang, J
Mei, T
Xu, A
Wang, Y
author_sort Yang, G
collection PubMed
description Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.
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spelling pubmed-27142422010-06-16 Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect Yang, G Wu, L Chen, S Zhu, L Huang, P Tong, L Zhao, Y Zhao, G Wang, J Mei, T Xu, A Wang, Y Br J Cancer Molecular Diagnostics Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect. Nature Publishing Group 2009-06-16 2009-05-19 /pmc/articles/PMC2714242/ /pubmed/19455142 http://dx.doi.org/10.1038/sj.bjc.6605087 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Yang, G
Wu, L
Chen, S
Zhu, L
Huang, P
Tong, L
Zhao, Y
Zhao, G
Wang, J
Mei, T
Xu, A
Wang, Y
Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
title Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
title_full Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
title_fullStr Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
title_full_unstemmed Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
title_short Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
title_sort mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714242/
https://www.ncbi.nlm.nih.gov/pubmed/19455142
http://dx.doi.org/10.1038/sj.bjc.6605087
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