Meta-analysis and Imputation Identifies a 109 kb Risk Haplotype Spanning TNFAIP3 Associated with Lupus Nephritis and Hematologic Manifestations

TNFAIP3 encodes the ubiquitin modifying enzyme, A20, a key regulator of inflammatory signaling pathways. We previously reported association between TNFAIP3 variants and systemic lupus erythematosus (SLE). In order to further localize the risk variant(s), we performed a meta-analysis using genetic da...

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Detalles Bibliográficos
Autores principales: Bates, Jared S., Lessard, Christopher J., Leon, Joanlise M., Nguyen, Thuan, Battiest, Laura J., Rodgers, Justin, Kaufman, Kenneth M., James, Judith A., Gilkeson, Gary S., Kelly, Jennifer A., Humphrey, Mary Beth, Harley, John B., Gray-McGuire, Courtney, Moser, Kathy L., Gaffney, Patrick M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714405/
https://www.ncbi.nlm.nih.gov/pubmed/19387456
http://dx.doi.org/10.1038/gene.2009.31

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