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Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

BACKGROUND: Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such a...

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Detalles Bibliográficos
Autores principales:	Cheung, Chun Hei Antonio, Chen, Huang-Hui, Kuo, Ching-Chuan, Chang, Chi-Yen, Coumar, Mohane S, Hsieh, Hsing-Pang, Chang, Jang-Yang
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714493/ https://www.ncbi.nlm.nih.gov/pubmed/19575780 http://dx.doi.org/10.1186/1476-4598-8-43

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