Cargando…

BRIT1/MCPH1 Links Chromatin Remodeling to DNA Damage Response

To detect and repair damaged DNA, DNA damage response proteins need to overcome the barrier of condensed chromatin to gain access to DNA lesions1. ATP-dependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin in DNA repair2–3. However, the mechanism mediati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Guang, Yim, Eun-Kyoung, Dai, Hui, Jackson, Andrew P., van der Burgt, Ineke, Pan, Mei-Ren, Hu, Ruozhen, Li, Kaiyi, Lin, Shiaw-Yih
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714531/ https://www.ncbi.nlm.nih.gov/pubmed/19525936 http://dx.doi.org/10.1038/ncb1895

Ejemplares similares

Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
por: Lin, Shiaw-Yih, et al.
Publicado: (2010)

Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model
por: Liang, Yulong, et al.
Publicado: (2014)

BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice
por: Liang, Yulong, et al.
Publicado: (2010)

The emerging role of MCPH1/BRIT1 in carcinogenesis
por: Alsolami, Mona, et al.
Publicado: (2023)

The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex
por: Ge, Chunmin, et al.
Publicado: (2015)

Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media
por: Chen, Jing, et al.
Publicado: (2013)

Correction: Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media
por: Chen, Jing, et al.
Publicado: (2013)

A Novel MCPH1 Isoform Complements the Defective Chromosome Condensation of Human MCPH1-Deficient Cells
por: Gavvovidis, Ioannis, et al.
Publicado: (2012)

Phenotypes in siblings with homozygous mutations of TRAPPC9 and/or MCPH1 support a bifunctional model of MCPH1
por: Duerinckx, Sarah, et al.
Publicado: (2018)

Brits bellenvat voor Europese kernfysici
Publicado: (1964)

Budget Brits hunt secrets of universe
Publicado: (2009)

MCPH1 keeps chromosomes strung out
por: Leslie, Mitch
Publicado: (2011)

Multifaceted Microcephaly-Related Gene MCPH1
por: Kristofova, Martina, et al.
Publicado: (2022)

Silencing BRIT1 Facilitates the Abilities of Invasiveness and Migration in Trophoblast Cells
por: Liu, Luping, et al.
Publicado: (2018)

Lockdown forces Brits to become 'DIY dentists'
Publicado: (2021)

MCPH1: a window into brain development and evolution
por: Pulvers, Jeremy N., et al.
Publicado: (2015)

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly
por: Cicconi, Alessandro, et al.
Publicado: (2020)

Connecting the Dots: From DNA Damage and Repair to Aging
por: Pan, Mei-Ren, et al.
Publicado: (2016)

Identification of Pathogenic Mutations in Primary Microcephaly- (MCPH-) Related Three Genes CENPJ, CASK, and MCPH1 in Consanguineous Pakistani Families
por: Khan, Niaz Muhammad, et al.
Publicado: (2022)

Reduced MCPH1 expression in breast cancer and response to chemotherapy
por: Richardson, J, et al.
Publicado: (2010)

MCPH1, a potential predictor for response to cancer chemotherapy
por: Bell, SM, et al.
Publicado: (2008)

MCPH1, beyond its role deciding the brain size
por: Kristofova, Martina, et al.
Publicado: (2021)

Week in Review: How a Brit set the web free
Publicado: (2009)

Overexpression of MCPH1 inhibits the migration and invasion of lung cancer cells
por: Wu, Xiaobin, et al.
Publicado: (2018)

Microcephaly family protein MCPH1 stabilizes RAD51 filaments
por: Chang, Hao-Yen, et al.
Publicado: (2020)

MCPH1: A Novel Case Report and a Review of the Literature
por: Caraffi, Stefano Giuseppe, et al.
Publicado: (2022)

Phylogeny and adaptive evolution of the brain-development gene microcephalin (MCPH1) in cetaceans
por: McGowen, Michael R, et al.
Publicado: (2011)

The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice
por: Wang, Yaru, et al.
Publicado: (2022)

Meet the Brit couple who's 'Big Bang' beneath the sheets actually worked!
Publicado: (2008)

CMA analysis identifies homozygous deletion of MCPH1 in 2 brothers with primary Microcephaly-1
por: Hemmat, Morteza, et al.
Publicado: (2017)

MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
por: Yamashita, Daisuke, et al.
Publicado: (2011)

MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis
por: Arroyo, M., et al.
Publicado: (2017)

The N-terminal BRCT domain determines MCPH1 function in brain development and fertility
por: Liu, Xiaoqian, et al.
Publicado: (2021)

BRG1 Promotes chromatin remodeling around DNA damage sites
por: Qi, Wenjing, et al.
Publicado: (2018)

Prenatal Identification of a Novel Mutation in the MCPH1 Gene Associated with Autosomal Recessive Primary Microcephaly (MCPH) Using Next Generation Sequencing (NGS): A Case Report and Review of the Literature
por: Papoulidis, Ioannis, et al.
Publicado: (2022)

Chromatin Remodeling, DNA Damage Repair and Aging
por: Liu, Baohua, et al.
Publicado: (2012)

Remodelers move chromatin in response to DNA damage
por: Seeber, Andrew, et al.
Publicado: (2014)

Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function
por: Trimborn, Marc, et al.
Publicado: (2010)

Novel compound heterozygous mutations in MCPH1 gene causes primary microcephaly in Saudi family
por: Naseer, Muhammad I., et al.
Publicado: (2018)

Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage
por: Min, Sunwoo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_96ricmqc3ootr00dnqnrr01kks