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Insights into the role of Val45 and Gln182 of Escherichia coli MutY in DNA substrate binding and specificity
BACKGROUND: Escherichia coli MutY (EcMutY) reduces mutagenesis by removing adenines paired with guanines or 7,8-dihydro-8-oxo-guanines (8-oxoG). V45 and Q182 of EcMutY are considered to be the key determinants of adenine specificity. Both residues are spatially close to each other in the active site...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714593/ https://www.ncbi.nlm.nih.gov/pubmed/19523222 http://dx.doi.org/10.1186/1471-2091-10-19 |