Reverse Engineering of the Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are properly attached to the mitotic spindle. Inhibiti...

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Detalles Bibliográficos
Autores principales: Doncic, Andreas, Ben-Jacob, Eshel, Einav, Shmuel, Barkai, Naama
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714964/
https://www.ncbi.nlm.nih.gov/pubmed/19652707
http://dx.doi.org/10.1371/journal.pone.0006495

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