Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

Immunoglobulin class switch recombination (CSR) is initiated by DNA breaks triggered by activation-induced cytidine deaminase (AID). These breaks activate DNA damage response proteins to promote appropriate repair and long-range recombination. Aberrant processing of these breaks, however, results in...

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Detalles Bibliográficos
Autores principales: Robert, Isabelle, Dantzer, Françoise, Reina-San-Martin, Bernardo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715026/
https://www.ncbi.nlm.nih.gov/pubmed/19364882
http://dx.doi.org/10.1084/jem.20082468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715026/
https://www.ncbi.nlm.nih.gov/pubmed/19364882
http://dx.doi.org/10.1084/jem.20082468

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