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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

Immunoglobulin class switch recombination (CSR) is initiated by DNA breaks triggered by activation-induced cytidine deaminase (AID). These breaks activate DNA damage response proteins to promote appropriate repair and long-range recombination. Aberrant processing of these breaks, however, results in...

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Detalles Bibliográficos
Autores principales:	Robert, Isabelle, Dantzer, Françoise, Reina-San-Martin, Bernardo
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715026/ https://www.ncbi.nlm.nih.gov/pubmed/19364882 http://dx.doi.org/10.1084/jem.20082468

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