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Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

Repetitive DNA sequences in the immunoglobulin switch μ region form RNA-containing secondary structures and undergo hypermutation by activation-induced deaminase (AID). To examine how DNA structure affects transcription and hypermutation, we mapped the position of RNA polymerase II molecules and mut...

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Detalles Bibliográficos
Autores principales:	Rajagopal, Deepa, Maul, Robert W., Ghosh, Amalendu, Chakraborty, Tirtha, Khamlichi, Ahmed Amine, Sen, Ranjan, Gearhart, Patricia J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715057/ https://www.ncbi.nlm.nih.gov/pubmed/19433618 http://dx.doi.org/10.1084/jem.20082514

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