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CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids
The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only in mycobacteria, but its discovery raises the possibility that ribosomally pro...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715062/ https://www.ncbi.nlm.nih.gov/pubmed/19468063 http://dx.doi.org/10.1084/jem.20082480 |
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por Van Rhijn, Ildiko, Young, David C., De Jong, Annemieke, Vazquez, Jenny, Cheng, Tan-Yun, Talekar, Rahul, Barral, Duarte C., León, Luis, Brenner, Michael B., Katz, Joel T., Riese, Richard, Ruprecht, Ruth M., O'Connor, Peter B., Costello, Catherine E., Porcelli, Steven A., Briken, Volker, Moody, D. Branch
Publicado 2009
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Publicado 2009
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Texto