Cholera toxin inhibits IL-12 production and CD8α(+) dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

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Prior studies have demonstrated that cholera toxin (CT) and other cAMP-inducing factors inhibit interleukin (IL)-12 production from monocytes and dendritic cells (DCs). We show that CT inhibits Th1 responses in vivo in mice infected with Toxoplasma gondii. This correlated with low serum IL-12 levels...

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Detalles Bibliográficos
Autores principales: la Sala, Andrea, He, Jianping, Laricchia-Robbio, Leopoldo, Gorini, Stefania, Iwasaki, Akiko, Braun, Michael, Yap, George S., Sher, Alan, Ozato, Keiko, Kelsall, Brian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715075/
https://www.ncbi.nlm.nih.gov/pubmed/19487420
http://dx.doi.org/10.1084/jem.20080912
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