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Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN product...

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Autores principales: Cao, Wei, Bover, Laura, Cho, Minkwon, Wen, Xiaoxia, Hanabuchi, Shino, Bao, Musheng, Rosen, David B., Wang, Yi-Hong, Shaw, Joanne L., Du, Qiumei, Li, Chun, Arai, Naoko, Yao, Zhengbin, Lanier, Lewis L., Liu, Yong-Jun
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715090/
https://www.ncbi.nlm.nih.gov/pubmed/19564354
http://dx.doi.org/10.1084/jem.20090547
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author Cao, Wei
Bover, Laura
Cho, Minkwon
Wen, Xiaoxia
Hanabuchi, Shino
Bao, Musheng
Rosen, David B.
Wang, Yi-Hong
Shaw, Joanne L.
Du, Qiumei
Li, Chun
Arai, Naoko
Yao, Zhengbin
Lanier, Lewis L.
Liu, Yong-Jun
author_facet Cao, Wei
Bover, Laura
Cho, Minkwon
Wen, Xiaoxia
Hanabuchi, Shino
Bao, Musheng
Rosen, David B.
Wang, Yi-Hong
Shaw, Joanne L.
Du, Qiumei
Li, Chun
Arai, Naoko
Yao, Zhengbin
Lanier, Lewis L.
Liu, Yong-Jun
author_sort Cao, Wei
collection PubMed
description Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7–FcϵRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC’s IFN responses through ILT7 in a negative feedback fashion.
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spelling pubmed-27150902010-01-06 Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction Cao, Wei Bover, Laura Cho, Minkwon Wen, Xiaoxia Hanabuchi, Shino Bao, Musheng Rosen, David B. Wang, Yi-Hong Shaw, Joanne L. Du, Qiumei Li, Chun Arai, Naoko Yao, Zhengbin Lanier, Lewis L. Liu, Yong-Jun J Exp Med Article Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7–FcϵRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC’s IFN responses through ILT7 in a negative feedback fashion. The Rockefeller University Press 2009-07-06 /pmc/articles/PMC2715090/ /pubmed/19564354 http://dx.doi.org/10.1084/jem.20090547 Text en © 2009 Cao et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Article
Cao, Wei
Bover, Laura
Cho, Minkwon
Wen, Xiaoxia
Hanabuchi, Shino
Bao, Musheng
Rosen, David B.
Wang, Yi-Hong
Shaw, Joanne L.
Du, Qiumei
Li, Chun
Arai, Naoko
Yao, Zhengbin
Lanier, Lewis L.
Liu, Yong-Jun
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
title Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
title_full Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
title_fullStr Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
title_full_unstemmed Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
title_short Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
title_sort regulation of tlr7/9 responses in plasmacytoid dendritic cells by bst2 and ilt7 receptor interaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715090/
https://www.ncbi.nlm.nih.gov/pubmed/19564354
http://dx.doi.org/10.1084/jem.20090547
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