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Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression

Treatment of patients with allergic asthma using low doses of peptides containing T cell epitopes from Fel d 1, the major cat allergen, reduces allergic sensitization and improves surrogate markers of disease. Here, we demonstrate a key immunological mechanism, linked epitope suppression, associated...

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Detalles Bibliográficos
Autores principales:	Campbell, John D., Buckland, Karen F., McMillan, Sarah J., Kearley, Jennifer, Oldfield, William L.G., Stern, Lawrence J., Grönlund, Hans, van Hage, Marianne, Reynolds, Catherine J., Boyton, Rosemary J., Cobbold, Stephen P., Kay, A. Barry, Altmann, Daniel M., Lloyd, Clare M., Larché, Mark
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715096/ https://www.ncbi.nlm.nih.gov/pubmed/19528258 http://dx.doi.org/10.1084/jem.20082901

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