Settling the thymus: immigration requirements

Thymus settling by precursor cells is essential for the production of T cells, yet the immigration requirements are poorly defined. P-selectin and CC chemokine receptor-9 (CCR9) are involved, and settling is favored when existing residents have moved on. A new study strengthens the correlation betwe...

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Detalles Bibliográficos
Autor principal: Cyster, Jason G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715109/
https://www.ncbi.nlm.nih.gov/pubmed/19349460
http://dx.doi.org/10.1084/jem.20090458
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author Cyster, Jason G.
author_facet Cyster, Jason G.
author_sort Cyster, Jason G.
collection PubMed
description Thymus settling by precursor cells is essential for the production of T cells, yet the immigration requirements are poorly defined. P-selectin and CC chemokine receptor-9 (CCR9) are involved, and settling is favored when existing residents have moved on. A new study strengthens the correlation between niche emptying and the induction of thymic P-selectin and CCR9 ligand, and provides evidence for feedback from the periphery to thymic P-selectin expression via sphingosine-1-phosphate.
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spelling pubmed-27151092009-10-13 Settling the thymus: immigration requirements Cyster, Jason G. J Exp Med Commentary Thymus settling by precursor cells is essential for the production of T cells, yet the immigration requirements are poorly defined. P-selectin and CC chemokine receptor-9 (CCR9) are involved, and settling is favored when existing residents have moved on. A new study strengthens the correlation between niche emptying and the induction of thymic P-selectin and CCR9 ligand, and provides evidence for feedback from the periphery to thymic P-selectin expression via sphingosine-1-phosphate. The Rockefeller University Press 2009-04-13 /pmc/articles/PMC2715109/ /pubmed/19349460 http://dx.doi.org/10.1084/jem.20090458 Text en © 2009 Cyster This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Cyster, Jason G.
Settling the thymus: immigration requirements
title Settling the thymus: immigration requirements
title_full Settling the thymus: immigration requirements
title_fullStr Settling the thymus: immigration requirements
title_full_unstemmed Settling the thymus: immigration requirements
title_short Settling the thymus: immigration requirements
title_sort settling the thymus: immigration requirements
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715109/
https://www.ncbi.nlm.nih.gov/pubmed/19349460
http://dx.doi.org/10.1084/jem.20090458
work_keys_str_mv AT cysterjasong settlingthethymusimmigrationrequirements

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