Cargando…

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

The molecular mechanisms underlying the development of hepatocellular carcinoma are not fully understood. Liver-specific signal transducer and activator of transcription (STAT) 5A/B–null mice (STAT5-LKO) were treated with carbon tetrachloride (CCl(4)), and histological analyses revealed liver fibros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hosui, Atsushi, Kimura, Akiko, Yamaji, Daisuke, Zhu, Bing-mei, Na, Risu, Hennighausen, Lothar
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715112/ https://www.ncbi.nlm.nih.gov/pubmed/19332876 http://dx.doi.org/10.1084/jem.20080003

Ejemplares similares

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration
por: Yamaji, Daisuke, et al.
Publicado: (2013)

Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation
por: Willi, Michaela, et al.
Publicado: (2016)

Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium
por: Groner, Bernd, et al.
Publicado: (2000)

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice
por: Fu, Shu-Ping, et al.
Publicado: (2017)

Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes
por: Yoo, Kyung Hyun, et al.
Publicado: (2015)

Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers
por: Hennighausen, Lothar, et al.
Publicado: (2020)

Cytokines and STATs in Liver Fibrosis
por: Kong, Xiaoni, et al.
Publicado: (2012)

Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy
por: Hennighausen, Lothar, et al.
Publicado: (2020)

MiR-21 Is under Control of STAT5 but Is Dispensable for Mammary Development and Lactation
por: Feuermann, Yonatan, et al.
Publicado: (2014)

Hierarchy within the mammary STAT5-driven Wap super-enhancer
por: Shin, Ha Youn, et al.
Publicado: (2016)

TGF-β co-opts STAT3-STAT4 signaling to promote human T follicular helper cell differentiation
por: Schmitt, Nathalie, et al.
Publicado: (2014)

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules
por: Kang, Keunsoo, et al.
Publicado: (2013)

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
por: Zehender, Ariella, et al.
Publicado: (2018)

The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3
por: Németh, Ágnes, et al.
Publicado: (2019)

CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways
por: Lin, In-Yu, et al.
Publicado: (2018)

Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
por: Zhu, Bing-Mei, et al.
Publicado: (2012)

STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling
por: Wang, Gaohang, et al.
Publicado: (2015)

An autoregulatory enhancer controls mammary-specific STAT5 functions
por: Metser, Gil, et al.
Publicado: (2016)

Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules
por: Jankowski, Jakub, et al.
Publicado: (2021)

Peroxiredoxin 5 Protects TGF-β Induced Fibrosis by Inhibiting Stat3 Activation in Rat Kidney Interstitial Fibroblast Cells
por: Choi, Hoon-In, et al.
Publicado: (2016)

Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling
por: Huang, Fengjuan, et al.
Publicado: (2019)

Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGF-β1 Signaling Pathway
por: Ruan, Hao, et al.
Publicado: (2021)

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity
por: Lee, Ji-Yeon, et al.
Publicado: (2008)

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
por: Kollmann, Sebastian, et al.
Publicado: (2019)

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans
por: Lyons, J.J., et al.
Publicado: (2017)

TGF‐β/Smad and JAK/STAT pathways are involved in the anti‐fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis
por: Xu, Shizan, et al.
Publicado: (2020)

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia
por: Hoelbl, Andrea, et al.
Publicado: (2010)

Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5–Dusp axis in the osteoclast
por: Hirose, Jun, et al.
Publicado: (2014)

Evaluation of Stat5 as a potential drug target in bcr/abl-induced leukemias
por: Hölbl, Andrea, et al.
Publicado: (2008)

Correction: ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans
por: Lyons, J.J., et al.
Publicado: (2017)

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
por: Villarino, Alejandro V., et al.
Publicado: (2007)

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells
por: Villarino, Alejandro V., et al.
Publicado: (2017)

Influence of increased physical activity without body weight loss on hepatic inflammation in patients with nonalcoholic fatty liver disease
por: Asada, Fuminari, et al.
Publicado: (2020)

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
por: Miyoshi, Keiko, et al.
Publicado: (2001)

Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGFβ1 Transgenic Mice
por: Guadagnin, Eleonora, et al.
Publicado: (2015)

STAT5 is critical in Dendritic Cells for development of T(H)2- but not T(H)1-dependent Immunity
por: Bell, Bryan D., et al.
Publicado: (2013)

STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis
por: Lee, Jongwon, et al.
Publicado: (2016)

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways
por: Wang, Jingyu, et al.
Publicado: (2021)

STAT1β enhances STAT1 function by protecting STAT1α from degradation in esophageal squamous cell carcinoma
por: Zhang, Ying, et al.
Publicado: (2017)

T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis
por: Schultz, Aaron B., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ior8t51fb3heqr2u5ucol1t1su