Cargando…

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200 CGG•CCG repeat tract in the 5′ UTR of the FMR1 gene, and alleles prone to fragility are associated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumari, Daman, Somma, Valentina, Nakamura, Asako J., Bonner, William M., D’Ambrosio, Ettoré, Usdin, Karen
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715245/ https://www.ncbi.nlm.nih.gov/pubmed/19465392 http://dx.doi.org/10.1093/nar/gkp391

Ejemplares similares

ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice
por: Entezam, Ali, et al.
Publicado: (2009)

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA
por: Bailey, Laura J., et al.
Publicado: (2009)

AT-dinucleotide rich sequences drive fragile site formation
por: Irony-Tur Sinai, Michal, et al.
Publicado: (2019)

Secondary structure formation and DNA instability at fragile site FRA16B
por: Burrow, Allison A., et al.
Publicado: (2010)

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability
por: Pladevall-Morera, David, et al.
Publicado: (2019)

The fragility of a structurally diverse duplication block triggers recurrent genomic amplification
por: Suzuki, Ryusuke, et al.
Publicado: (2020)

Replication stress induces accumulation of FANCD2 at central region of large fragile genes
por: Okamoto, Yusuke, et al.
Publicado: (2018)

The genomic landscape of 8-oxodG reveals enrichment at specific inherently fragile promoters
por: Gorini, Francesca, et al.
Publicado: (2020)

FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells
por: Pentzold, Constanze, et al.
Publicado: (2018)

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells
por: Bhat, Audesh, et al.
Publicado: (2013)

Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function
por: Gellon, Lionel, et al.
Publicado: (2019)

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D
por: Shah, Sandeep N., et al.
Publicado: (2010)

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells
por: Fernandes, Rita Valador, et al.
Publicado: (2023)

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes
por: Cohen, Isadora S., et al.
Publicado: (2015)

Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
por: Suspène, Rodolphe, et al.
Publicado: (2017)

Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders
por: Usdin, Karen, et al.
Publicado: (2015)

Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity
por: Dickey, Jennifer S., et al.
Publicado: (2012)

Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells
por: Tan, Kang Wei, et al.
Publicado: (2015)

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress
por: Simoneau, Antoine, et al.
Publicado: (2016)

DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP
por: Mimmler, Maximilian, et al.
Publicado: (2016)

Monitoring bypass of single replication-blocking lesions by damage avoidance in the Escherichia coli chromosome
por: Pagès, Vincent, et al.
Publicado: (2012)

Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency
por: Di Domenico, Enea Gino, et al.
Publicado: (2013)

SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
por: Biacsi, Rea, et al.
Publicado: (2008)

Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements
por: Elango, Rajula, et al.
Publicado: (2019)

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage
por: Rizzo, Angela, et al.
Publicado: (2017)

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
por: Riccio, Amanda A., et al.
Publicado: (2016)

Ultraviolet-induced RNA:DNA hybrids interfere with chromosomal DNA synthesis
por: Kouzminova, Elena A, et al.
Publicado: (2021)

DNA catenation maintains structure of human metaphase chromosomes
por: Bauer, David L. V., et al.
Publicado: (2012)

Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA
por: Furukohri, Asako, et al.
Publicado: (2012)

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome
por: Erliandri, Indri, et al.
Publicado: (2014)

Pharmacological Reactivation of the Silenced FMR1 Gene as a Targeted Therapeutic Approach for Fragile X Syndrome
por: Kumari, Daman, et al.
Publicado: (2019)

Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A–MDC1–TOPBP1 complex from spindle pole to chromosomes
por: Leem, Jiyeon, et al.
Publicado: (2023)

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment
por: Schipler, Agnes, et al.
Publicado: (2016)

OGT restrains the expansion of DNA damage signaling
por: Chen, Qiang, et al.
Publicado: (2016)

The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm
por: Ayuda-Durán, Pilar, et al.
Publicado: (2014)

Inhibition of DNA damage repair by artificial activation of PARP with siDNA
por: Croset, Amelie, et al.
Publicado: (2013)

Quantifying the stability of oxidatively damaged DNA by single-molecule DNA stretching
por: McCauley, Micah J, et al.
Publicado: (2018)

A novel nucleoid-associated protein coordinates chromosome replication and chromosome partition
por: Taylor, James A., et al.
Publicado: (2017)

A role for chromatin remodellers in replication of damaged DNA
por: Niimi, Atsuko, et al.
Publicado: (2012)

Genetic vulnerabilities upon inhibition of DNA damage response
por: Wang, Chao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_psuv8a3ogg5d03fqf7jna6dlvi