Structure of the RAG1 nonamer-binding domain with DNA reveals a dimer that mediates DNA synapsis

The products of recombination activating genes (RAG) 1 and 2 mediate the assembly of antigen receptor genes during lymphocyte development in a process known as V(D)J recombination. Lack of structural information for the RAG proteins has hindered mechanistic studies of this reaction. We report here t...

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Detalles Bibliográficos
Autores principales: Fang Yin, Fang, Bailey, Scott, Innis, C. Axel, Ciubotaru, Mihai, Kamtekar, Satwik, Steitz, Thomas A., Schatz, David G.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715281/
https://www.ncbi.nlm.nih.gov/pubmed/19396172
http://dx.doi.org/10.1038/nsmb.1593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715281/
https://www.ncbi.nlm.nih.gov/pubmed/19396172
http://dx.doi.org/10.1038/nsmb.1593

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