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Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells

BACKGROUND: Endothelin-1 (ET-1) is a potent vasoactive peptide, which induces vasoconstriction and proliferation in vascular smooth muscle cells (VSMCs) through activation of endothelin type A (ET(A)) and type B (ET(B)) receptors. The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-ac...

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Detalles Bibliográficos
Autores principales: Chen, Qing-wen, Edvinsson, Lars, Xu, Cang-Bao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715373/
https://www.ncbi.nlm.nih.gov/pubmed/19575782
http://dx.doi.org/10.1186/1471-2121-10-52