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Possible roles of Epstein-Barr virus in Castleman disease

BACKGROUND: Complete resection seemed to be curative in patients with Castleman disease of any location but the disease is likely to be reactive in its pathogenesis. The relation between Epstein-Barr virus and Castleman disease has not been elucidated. We tried to define the role of Epstein-Barr vir...

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Autores principales: Chen, Chih-Hao, Liu, Hung-Chang, Hung, Tzu-Ti, Liu, Tsang-Pai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715400/
https://www.ncbi.nlm.nih.gov/pubmed/19589162
http://dx.doi.org/10.1186/1749-8090-4-31
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author Chen, Chih-Hao
Liu, Hung-Chang
Hung, Tzu-Ti
Liu, Tsang-Pai
author_facet Chen, Chih-Hao
Liu, Hung-Chang
Hung, Tzu-Ti
Liu, Tsang-Pai
author_sort Chen, Chih-Hao
collection PubMed
description BACKGROUND: Complete resection seemed to be curative in patients with Castleman disease of any location but the disease is likely to be reactive in its pathogenesis. The relation between Epstein-Barr virus and Castleman disease has not been elucidated. We tried to define the role of Epstein-Barr virus in the pathogenesis of Castleman disease. METHODS: 20 cases of Castleman disease were retrospectively reviewed from 1993 to 2006. At least 2 to 4 representative sections of formalin-fixed, paraffin-embedded specimens from each patient were obtained to examine the presence of EBV and its localization by hematoxylin-eosin stain, immunohistochemistry, polymerase chain reaction and In-situ hybridization RESULTS: Hyaline-vascular type was diagnosed in 18 cases, plasma cell type in 1 and mixed type in 1 case. All of them were positive for Epstein-Barr virus confirmed by PCR. For tumors that EBER(Epstein-Barr early region) signals mainly localized in the germinal centers have increased vascularity than cases with EBER detected in inter-follicular areas. CONCLUSION: There is a strong association between Castleman disease and Epstein-Barr virus. EBV may have a potential role in angiogenesis of Castleman disease. For smaller lesion with high activity of angiogenesis but not amenable for curative resection, anti-angiogenesis medications may have a potential role to control the disease.
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spelling pubmed-27154002009-07-25 Possible roles of Epstein-Barr virus in Castleman disease Chen, Chih-Hao Liu, Hung-Chang Hung, Tzu-Ti Liu, Tsang-Pai J Cardiothorac Surg Research Article BACKGROUND: Complete resection seemed to be curative in patients with Castleman disease of any location but the disease is likely to be reactive in its pathogenesis. The relation between Epstein-Barr virus and Castleman disease has not been elucidated. We tried to define the role of Epstein-Barr virus in the pathogenesis of Castleman disease. METHODS: 20 cases of Castleman disease were retrospectively reviewed from 1993 to 2006. At least 2 to 4 representative sections of formalin-fixed, paraffin-embedded specimens from each patient were obtained to examine the presence of EBV and its localization by hematoxylin-eosin stain, immunohistochemistry, polymerase chain reaction and In-situ hybridization RESULTS: Hyaline-vascular type was diagnosed in 18 cases, plasma cell type in 1 and mixed type in 1 case. All of them were positive for Epstein-Barr virus confirmed by PCR. For tumors that EBER(Epstein-Barr early region) signals mainly localized in the germinal centers have increased vascularity than cases with EBER detected in inter-follicular areas. CONCLUSION: There is a strong association between Castleman disease and Epstein-Barr virus. EBV may have a potential role in angiogenesis of Castleman disease. For smaller lesion with high activity of angiogenesis but not amenable for curative resection, anti-angiogenesis medications may have a potential role to control the disease. BioMed Central 2009-07-09 /pmc/articles/PMC2715400/ /pubmed/19589162 http://dx.doi.org/10.1186/1749-8090-4-31 Text en Copyright © 2009 Chen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Chih-Hao
Liu, Hung-Chang
Hung, Tzu-Ti
Liu, Tsang-Pai
Possible roles of Epstein-Barr virus in Castleman disease
title Possible roles of Epstein-Barr virus in Castleman disease
title_full Possible roles of Epstein-Barr virus in Castleman disease
title_fullStr Possible roles of Epstein-Barr virus in Castleman disease
title_full_unstemmed Possible roles of Epstein-Barr virus in Castleman disease
title_short Possible roles of Epstein-Barr virus in Castleman disease
title_sort possible roles of epstein-barr virus in castleman disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715400/
https://www.ncbi.nlm.nih.gov/pubmed/19589162
http://dx.doi.org/10.1186/1749-8090-4-31
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