Cargando…

Phagosomal membrane targeting of Irgm1 via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes mycobacterial immunity

Vertebrate immunity to infection enlists a new family of 47 kDa immunity-related GTPases (IRGs). One IRG in particular - Irgm1 - is essential for macrophage host defense against phagosomal pathogens including Mycobacterium tuberculosis (Mtb). Here we show Irgm1 targets the mycobacterial phagosome (P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tiwari, Sangeeta, Choi, Han-Pil, Matsuzawa, Takeshi, Pypaert, Marc, MacMicking, John D.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715447/ https://www.ncbi.nlm.nih.gov/pubmed/19620982 http://dx.doi.org/10.1038/ni.1759

Ejemplares similares

PtdIns(4,5)P(2) and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance
por: Cheng, Shiya, et al.
Publicado: (2015)

Probing PtdIns4P’s localization
por: Short, Ben
Publicado: (2014)

PtdIns(4,5)P2 and PtdIns(3,4,5)P3 dynamics during focal adhesions assembly and disassembly in a cancer cell line
por: ALFAHAD, Dhurgham, et al.
Publicado: (2020)

PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes
por: Henmi, Yuji, et al.
Publicado: (2016)

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2)
por: Hammond, Gerald R. V., et al.
Publicado: (2009)

PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking
por: Wood, Christopher S., et al.
Publicado: (2009)

Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy
por: Wurmser, Andrew E., et al.
Publicado: (2002)

Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P(2) synthesis
por: de la Cruz, Lizbeth, et al.
Publicado: (2022)

PtdIns (3,4,5) P3 Recruitment of Myo10 Is Essential for Axon Development
por: Yu, Huali, et al.
Publicado: (2012)

PTEN and Other PtdIns(3,4,5)P(3) Lipid Phosphatases in Breast Cancer
por: Csolle, Mariah P., et al.
Publicado: (2020)

PtdIns(3,4,5)P(3)-Dependent and -Independent Roles for PTEN in the Control of Cell Migration
por: Leslie, Nick R., et al.
Publicado: (2007)

RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P(2) signalling during Drosophila phototransduction
por: Yadav, Shweta, et al.
Publicado: (2015)

PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast
por: Obara, Keisuke, et al.
Publicado: (2011)

Link the channel activity to PtdIns(4,5)P(2) dynamics
por: Mori, Masayuki X
Publicado: (2014)

A protein complex that regulates PtdIns(3,5)P(2) levels
por: Michell, Robert H, et al.
Publicado: (2009)

Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP(2) in the Mouse
por: Anderson, Karen E., et al.
Publicado: (2013)

PtdIns4P on Dispersed Trans-Golgi Network Mediates NLRP3 Inflammasome Activation
por: Chen, Jueqi, et al.
Publicado: (2018)

PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P(3) Effector Signaling in Colorectal Cancer
por: Palmieri, Michelle, et al.
Publicado: (2023)

New insights into the functions of PtdIns(3,5)P(2) in the pathogenisis of neurodegenerative disorders
por: Tsuruta, Fuminori
Publicado: (2016)

PtdIns3P controls mTORC1 signaling through lysosomal positioning
por: Hong, Zhi, et al.
Publicado: (2017)

Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P(2)
por: Nigorikawa, Kiyomi, et al.
Publicado: (2015)

IPIP27 Coordinates PtdIns(4,5)P(2) Homeostasis for Successful Cytokinesis
por: Carim, Sabrya C., et al.
Publicado: (2019)

Computational studies of the binding profile of phosphoinositide PtdIns (3,4,5) P(3) with the pleckstrin homology domain of an oomycete cellulose synthase
por: Kuang, Guanglin, et al.
Publicado: (2016)

pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels
por: Naufer, Amriya, et al.
Publicado: (2018)

PtdIns(3,4)P(2), Lamellipodin, and VASP coordinate actin dynamics during phagocytosis in macrophages
por: Montaño-Rendón, Fernando, et al.
Publicado: (2022)

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P(2) but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation
por: Sbrissa, Diego, et al.
Publicado: (2018)

Inositol hexakisphosphate kinase 1 (InsP6K1) regulates neutrophil function in innate immunity by inhibiting PtdIns(3,4,5)P3 signaling
por: Prasad, Amit, et al.
Publicado: (2011)

Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling
por: Lu, Nan, et al.
Publicado: (2011)

PtdIns4P-mediated electrostatic forces influence S-acylation of peripheral proteins at the Golgi complex
por: Chumpen Ramirez, Sabrina, et al.
Publicado: (2020)

A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples
por: Chicanne, Gaëtan, et al.
Publicado: (2012)

The PtdIns3‐phosphatase MTMR3 interacts with mTORC1 and suppresses its activity
por: Hao, Feike, et al.
Publicado: (2016)

Phospholipase Cζ binding to PtdIns(4,5)P(2) requires the XY-linker region
por: Nomikos, Michail, et al.
Publicado: (2011)

Investigation of the PtdIns(4,5)P(2 )dependence of plasma membrane receptor endocytosis in living cells
por: Tóth, Dániel, et al.
Publicado: (2009)

Legionella-Containing Vacuoles Capture PtdIns(4)P-Rich Vesicles Derived from the Golgi Apparatus
por: Weber, Stephen, et al.
Publicado: (2018)

The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
por: Del Signore, Steven J., et al.
Publicado: (2019)

Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3
por: Baird, Dan, et al.
Publicado: (2008)

The PtdIns3P phosphatase MtMP promotes symbiotic nitrogen fixation via mitophagy in Medicago truncatula
por: Xue, Qixia, et al.
Publicado: (2023)

Fab1p Is Essential for PtdIns(3)P 5-Kinase Activity and the Maintenance of Vacuolar Size and Membrane Homeostasis
por: Gary, Jonathan D., et al.
Publicado: (1998)

Alteration of Epithelial Structure and Function Associated with PtdIns(4,5)P(2) Degradation by a Bacterial Phosphatase
por: Mason, David, et al.
Publicado: (2007)

Clathrin and AP2 are required for PtdIns(4,5)P(2)-mediated formation of LRP6 signalosomes
por: Kim, Ingyu, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2gcv3cd8kq1v1nuh1dn0s84i25