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The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis

Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and IL-18 chosen in AD patients by ELISA assay. Forty patie...

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Autores principales: Narbutt, Joanna, Lesiak, Aleksandra, Sysa-Jedrzeiowska, Anna, Zakrzewski, Marcin, Bogaczewicz, Jarosław, Stelmach, Iwona, Kuna, Piotr
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715822/
https://www.ncbi.nlm.nih.gov/pubmed/19639049
http://dx.doi.org/10.1155/2009/269541
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author Narbutt, Joanna
Lesiak, Aleksandra
Sysa-Jedrzeiowska, Anna
Zakrzewski, Marcin
Bogaczewicz, Jarosław
Stelmach, Iwona
Kuna, Piotr
author_facet Narbutt, Joanna
Lesiak, Aleksandra
Sysa-Jedrzeiowska, Anna
Zakrzewski, Marcin
Bogaczewicz, Jarosław
Stelmach, Iwona
Kuna, Piotr
author_sort Narbutt, Joanna
collection PubMed
description Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and IL-18 chosen in AD patients by ELISA assay. Forty patients (mean age 11.4 years old) with AD and 50 healthy controls were enrolled into the study. The patients and controls were divided into two age categories: under 10 years old (Group 1 and Control 1) and over 10 years old (Group 2 and Control 2). Significantly lower serum concentration of CXCL-9, CXCL-10, CCL-17, and IL-18 and higher concentration of CXCL-12 and CCL-27 were found in Group 1 when compared to Control 1. In Group 2 serum concentration of CXCL-12, CCL-17, CCL-22 was higher than in Control 2. The obtained results indicate the imbalance in chemokine serum levels in AD what suggests their role in the disease pathogenesis.
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spelling pubmed-27158222009-07-28 The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis Narbutt, Joanna Lesiak, Aleksandra Sysa-Jedrzeiowska, Anna Zakrzewski, Marcin Bogaczewicz, Jarosław Stelmach, Iwona Kuna, Piotr Mediators Inflamm Research Article Atopic dermatitis (AD) is an inflammatory skin disease in which pathogenesis chemokines are partially involved. The aim of the paper was to assess the serum level of CXCL-9, CXCL-10, CXCL-11, CXCL-12, CCL-17, CCL-20, CCL-21, CCL-22, CCL-27, and IL-18 chosen in AD patients by ELISA assay. Forty patients (mean age 11.4 years old) with AD and 50 healthy controls were enrolled into the study. The patients and controls were divided into two age categories: under 10 years old (Group 1 and Control 1) and over 10 years old (Group 2 and Control 2). Significantly lower serum concentration of CXCL-9, CXCL-10, CCL-17, and IL-18 and higher concentration of CXCL-12 and CCL-27 were found in Group 1 when compared to Control 1. In Group 2 serum concentration of CXCL-12, CCL-17, CCL-22 was higher than in Control 2. The obtained results indicate the imbalance in chemokine serum levels in AD what suggests their role in the disease pathogenesis. Hindawi Publishing Corporation 2009 2009-07-22 /pmc/articles/PMC2715822/ /pubmed/19639049 http://dx.doi.org/10.1155/2009/269541 Text en Copyright © 2009 Joanna Narbutt et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Narbutt, Joanna
Lesiak, Aleksandra
Sysa-Jedrzeiowska, Anna
Zakrzewski, Marcin
Bogaczewicz, Jarosław
Stelmach, Iwona
Kuna, Piotr
The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
title The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
title_full The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
title_fullStr The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
title_full_unstemmed The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
title_short The Imbalance in Serum Concentration of Th-1- and Th-2-Derived Chemokines as One of the Factors Involved in Pathogenesis of Atopic Dermatitis
title_sort imbalance in serum concentration of th-1- and th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715822/
https://www.ncbi.nlm.nih.gov/pubmed/19639049
http://dx.doi.org/10.1155/2009/269541
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