Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases

Recent studies of inherited neurodegenerative disorders have suggested a linkage between the propensity toward aggregation of mutant protein and disease onset. This is particularly apparent for polyglutamine (polyQ) diseases caused by expansion of CAG-trinucleotide repeats. However, a quantitative f...

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Detalles Bibliográficos
Autores principales: Sugaya, Keizo, Matsubara, Shiro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716343/
https://www.ncbi.nlm.nih.gov/pubmed/19602294
http://dx.doi.org/10.1186/1750-1326-4-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716343/
https://www.ncbi.nlm.nih.gov/pubmed/19602294
http://dx.doi.org/10.1186/1750-1326-4-29

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