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Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases
Recent studies of inherited neurodegenerative disorders have suggested a linkage between the propensity toward aggregation of mutant protein and disease onset. This is particularly apparent for polyglutamine (polyQ) diseases caused by expansion of CAG-trinucleotide repeats. However, a quantitative f...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716343/ https://www.ncbi.nlm.nih.gov/pubmed/19602294 http://dx.doi.org/10.1186/1750-1326-4-29 |